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ABSTRACT Objective: To assess the relationship between patients' and dentists' perceptions of shade selection and its impact on satisfaction with the prosthesis. Material and Methods: A single group pre-post study was conducted at the Prosthodontics department of a teaching hospital in India. One hundred ten participants were selected through a systematic random sampling technique with inclusion and exclusion criteria. Patients' attitudes regarding the aesthetics of their maxillary anterior teeth were recorded using a validated questionnaire. Shades for the intended prosthetic crown selected by the dentist and chosen by the patient were recorded separately, and patient satisfaction with the appearance of the final prosthesis was recorded. We used descriptive statistics followed by Pearson's Chi-square test and a binomial logistic regression model for inferential statistics. Results: 109 participant's data were available for final analysis. Patients choose lighter shades than the dentist's selection, which is statistically significant (p=0.000). 73.4% were satisfied with the final prosthesis, and the binomial logistic regression model identified using patient-selected shade for the final prosthesis was significantly associated with patients' satisfaction with the final prosthesis (OR=3.3, p=0.001). Conclusion: The patient's preference should be considered with the dentist's option when selecting a shade to create good esthetics.
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Humans , Animals , Adult , Patient Satisfaction , Dentists , Denture, Partial, Fixed , Esthetics, Dental , Chi-Square Distribution , Logistic Models , Color , Tooth CrownABSTRACT
Purpose: This study aimed to assess and compare the changes in peripapillary retinal nerve fiber layer (RNFL) thickness in nondiabetics and diabetics with various stages of diabetic retinopathy (DR). Methods: The study subjects were divided into four groups based on their diabetic status and findings, namely, controls (normal subjects without diabetes [NDM]), diabetics without retinopathy (NDR), nonproliferative DR (NPDR), and proliferative DR (PDR). Peripapillary RNFL thickness was assessed using optical coherence tomography. One?way analysis of variance (ANOVA) with the post?Tukey HSD test was done to compare RNFL thickness in different groups. The Pearson coefficient was used to determine the correlation. Results: There was statistically significant difference in measured average RNFL (F = 14.8000, P < 0.05), superior RNFL (F = 11.7768, P < 0.05), inferior RNFL (F = 12.9639, P < 0.05), nasal RNFL (F = 12.2134, P < 0.05), and temporal RNFL (F = 4.2668, P < 0.05) across the different study groups. Pairwise comparison showed that there was a statistically significant difference in RNFL measured (average and all quadrants) in patients with DR (NPDR and PDR) and the NDM control group (P < 0.05). In diabetics without retinopathy, the RNFL measured was reduced compared to controls, but it was statistically significant only in the superior quadrant (P < 0.05). Average RNFL and RNFL in all quadrants showed a small negative correlation with the severity of DR and it was statistically significant (P < 0.001). Conclusion: In our study, peripapillary RNFL thickness was reduced in diabetic retinopathy compared to normal controls and the thinning increased with the severity of DR. This was evident in the superior quadrant even before the fundus signs of DR set in
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The study aimed to reveal the phytochemical profile, free radical scavenging potential, and anticancer activity of Solanum lycopersicum L. leaf extract (SLLE). According to the study, SLLE contains plant secondary metabolites that are beneficial for health, like phenolics, flavonoids, ascorbic acid, alkaloids, and terpenoids. The SLLE has shown potential free radical scavenging potential in DPPH and ABTS free radical scavenging analysis and its EC50 values (concentration required to inhibit 50% of free radicals) were determined as 481.29 ± 33.82 and 527.56 ± 20.34 µg/mL, respectively. The SLLE has the ability to scavenge free radicals and could be used to treat illnesses brought on by oxidative stress. The anticancer activity of SLLE was assessed by MTT, LDH, micro-morphological, live/dead dual staining, and caspase-3 analysis. In the MTT assay, the IC50 value (concentration required to inhibit 50% of cell viability) of SLLE was determined as 190.41 ± 4.77 µg/mL. Furthermore, SLLE has shown potential anticancer activity by adversely affecting the plasma membrane integrity and escalating the caspase-3 levels. In the biomedical field, SLLE could be highly useful to treat cancer.
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This study was designed to systematically review and meta-analyze the functional and radiological outcomes between lateral and posterior approaches in adult degenerative scoliosis (ADS). Both lateral (lumbar, extreme, and oblique) and posterior interbody fusion (posterior lumbar and transforaminal) are used for deformity correction in patients with ADS with unclear comparison in this cohort of patients in the existing literature. A literature search using three electronic databases was performed to identify studies that reported outcomes of lateral (group L) and posterior interbody fusion (group P) in patients with ADS with curves of 10°–40°. Group P was further subdivided into minimally invasive surgery (MIS-P) and open posterior (Op-P) subgroups. Data on functional, radiological, and operative outcomes, length of hospital stay (LOHS), fusion rates, and complications were extracted and meta-analyzed using the random-effects model. A total of 18 studies (732 patients) met the inclusion criteria. No significant difference was found in functional and radiological outcomes between the two groups on data pooling. Total operative time in the MIS-P subgroup was less than that of group L (233.86 minutes vs. 401 minutes, p <0.05). The total blood loss in group L was less than that in the Op-P subgroup(477 mL vs. 1,325.6 mL, p <0.05). Group L had significantly less LOHS than the Op-P subgroup (4.15 days vs. 13.5 days, p <0.05). No significant difference was seen in fusion rates, but complications were seen except for transient sensorimotor weakness (group L: 24.3%, group P: 5.6%; p <0.05). Complications, such as postoperative thigh pain (7.7%), visceral injuries (2%), and retrograde ejaculation (3.7%), were seen only in group L while adjacent segment degeneration was seen only in group P (8.6%). Lateral approach has an advantage in blood loss and LOHS over the Op-P subgroup. The MIS-P subgroup has less operative time than group L, but with comparable blood loss and LOHS. No significant difference was found in functional, radiological, fusion rates, pseudoarthrosis, and complications, except for transient sensorimotor deficits. Few complications were approach-specific in each group.
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Background: The coexistence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) is termed “Overlap syndrome (OS).” Objectives: The present study aimed at estimating the prevalence of OS among patients diagnosed with OSA. Methods: It was a prospective observational study conducted on patients presenting to respiratory medicine outpatient department (sleep clinic) with symptoms of sleep-disordered breathing and was found to have OSA by overnight polysomnography. These patients were then subjected to spirometry to diagnose COPD. Results: The prevalence of OS in the study population was found to be 41.3%. Excessive daytime sleepiness was found to be higher in overlap group patients (P = 0.033), the difference was statistically significant. The mean age (59.9 ± 9.6 years) was found to be high in the OS group compared to those without the same. The mean forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and FEV1/FVC (pre? and postbronchodilator) spirometry parameters were found to be lower in patients with OS. Conclusion: The study showed that the prevalence of OS in the present study was 41.3%. Excessive daytime sleepiness and age >60 years were risk factors for OS in a patient with OSA. OS patients had lower pulmonary function values.
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Background & objectives: COVID-19 has been a global pandemic since early 2020. It has diverse clinical manifestations, but consistent immunological and metabolic correlates of disease severity and protection are not clear. This study was undertaken to compare seropositivity rate, antibody levels against nucleocapsid and spike proteins, virus neutralization and metabolites between adult and child COVID-19 patients. Methods: Plasma samples from naïve control (n=14) and reverse transcription (RT)-PCR positive COVID-19 participants (n=132) were tested for reactivity with nucleocapsid and spike proteins by ELISA, neutralization of SARS-CoV-2 infectivity in Vero cells and metabolites by 1H nuclear magnetic resonance (NMR) spectroscopy. Results: An ELISA platform was developed using nucleocapsid and spike proteins for COVID-19 serosurvey. The participants showed greater seropositivity for nucleocapsid (72%) than spike (55.3%), and males showed higher seropositivity than females for both the proteins. Antibody levels to both the proteins were higher in intensive care unit (ICU) than ward patients. Children showed lower seropositivity and antibody levels than adults. In contrast to ICU adults (81.3%), ICU children (33.3%) showed lower seropositivity for spike. Notably, the neutralization efficiency correlated with levels of anti-nucleocapsid antibodies. The levels of plasma metabolites were perturbed differentially in COVID-19 patients as compared with the naive controls. Interpretation & conclusions: Our results reflect the complexity of human immune response and metabolome to SARS-CoV-2 infection. While innate and cellular immune responses are likely to be a major determinant of disease severity and protection, antibodies to multiple viral proteins likely affect COVID-19 pathogenesis. In children, not adults, lower seropositivity rate for spike was associated with disease severity
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A wound is a break in the integrity of the skin or tissues often which may be associated with disruption of the structure and function. Globally, the magnitude of acute wounds as a healthcare problem is sharply rising mainly due to industrialization. There is still a need to revisit the ancient healing methods by using traditional medicine aiming to discover a wound healing drug with better protection, rapid granulation changes, least side effects, good bio-availability and low cost. A folk medicinal plant Humboldtia vahliana Wight. belongs to the family Fabaceae, is a medium sized tree with rough, dark brown bark mottled with white. Its stem bark is used for wound healing among the tribes. Aims and objectives: The study aims to evaluate the in-vivo wound healing action of Humboldtia vahliana Wight. through excision and incision animal wound models. Methodology: 36 male Wistar albino rats weighing 150-250gm. were selected and made into 3 groups each for both incision and excision wounds, i.e., control, standard and trial group -each containing 6 rats. The trial drug Humboldtia vahliana Wight. was applied over the wound area in the form of ‘Kalka’. In excision wound model, percentage of wound contraction was the parameter for the study and was achieved by using Planimetry. In incision wound model, tensile strength was the parameter and was achieved by Local Tensiometer. Results: In case of both Incision as well as Excision wound contraction study, the data shows a statistically non-significant increase in percentage wound contraction of Trial group when compared to Control and Standard groups. Interpretation and Conclusion: The stem bark of Humboldtia vahliana Wight. showed better wound healing action in Wistar albino rats when percentage of efficacy or mean values were compared
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The aim of the study was to explore re incidences and re safety lacunae in Indian hospitals and recommend ways to improve it. Data from archive media of NDTV news, Indian Express, India Today, The New Indian Express, and Sakal e-paper available from July 2010 till April 2021 was analysed. Total 60 hospital re incidences from 16 states of India were covered. Ownership of the hospital, departments affected, time, month and cause of the re incidences, number of deaths and injuries, and lacunae in the re safety measures in Indian hospitals have been reported in this paper. Fire in the hospital not only leads to loss of human life but great economic loss. Although we may argue, we have plenty of lessons learned from the hospital re incidences in the past; the fact is that we are far away from properly applying those lessons to disaster response and recov'not;ery operations. All the Indian hospitals must adhere to Fire and Life Safety guidelines given by National Building Code of India, National Electrical Code standards and National Accreditation Board for Hospitals and Healthcare
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In the last few decades, hydroxyapatite (HA) has become one of the most highly prized biominerals in the biomedical industry for orthopedic and dental applications. The focus of this research was to synthesize biomimetic HA from Tridax procumbens (TP) leaf extract and investigate their antibiofilm properties. The HA was made using the sol-gel method and the HA-TP biocomposite was made by precipitation method. The d.nm size of HA and HA-TP biocomposite was determined as 193.28 and 258.14 d.nm, respectively. The zeta potential of HA and HA-TP biocomposite was determined as ?21.2 and ?18.3 mV, respectively, and found highly stable. The FTIR study revealed that phytochemicals of TP were successfully impregnated into HA-TP biocomposite. The HA and HA-TP biocomposite were found spherical and agglomerated from SEM analysis. In HR-TEM analysis, the average diameter of the HA and HA-TP biocomposite were 16.57 – 64.22 nm and 51.71 – 138.68 nm, respectively. According to the EDX analysis, HA is primarily composed of calcium, oxygen, and phosphate, whereas, HA-TP biocomposite is primarily composed of calcium, phosphate, oxygen, and carbon. In the antioxidant assay, the IC50 value (concentration required to scavenge 50% of free radicals) of HA-TP biocomposite was determined as 156.69 ± 14.02 and 180.21 ± 12.84 µg/mL in DPPH and ABTS free radical scavenging assays, respectively. The MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) of as-synthesized HA-TP biocomposite against Staphylococcus aureus – ATCC 13565 and Escherichia coli – MTCC 41 were observed as 181.09 ± 21.47 and 317.30 ± 41.03, and 157.59 ± 32.18 and 264.03 ± 21.58 µg/mL, respectively. The as-synthesized HA-TP biocomposite has detrimentally affected the biofilm formation of both the tested bacteria S. aureus – ATCC 13565 and E. coli – MTCC 41. The study concluded that the as-synthesized HA-TP biocomposite could be highly helpful in the biomedical field for alleviating oxidative-stress-related disorders and inhibiting microbial biofilm formation.
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While most patients with depression respond to pharmacotherapy and psychotherapy, about one-third will present treatment resistance to these interventions. For patients with treatment-resistant depression (TRD), invasive neurostimulation therapies such as vagus nerve stimulation, deep brain stimulation, and epidural cortical stimulation may be considered. We performed a narrative review of the published literature to identify papers discussing clinical studies with invasive neurostimulation therapies for TRD. After a database search and title and abstract screening, relevant English-language articles were analyzed. Vagus nerve stimulation, approved by the U.S. Food and Drug Administration as a TRD treatment, may take several months to show therapeutic benefits, and the average response rate varies from 15.2-83%. Deep brain stimulation studies have shown encouraging results, including rapid response rates (> 30%), despite conflicting findings from randomized controlled trials. Several brain regions, such as the subcallosal-cingulate gyrus, nucleus accumbens, ventral capsule/ventral striatum, anterior limb of the internal capsule, medial-forebrain bundle, lateral habenula, inferior-thalamic peduncle, and the bed-nucleus of the stria terminalis have been identified as key targets for TRD management. Epidural cortical stimulation, an invasive intervention with few reported cases, showed positive results (40-60% response), although more extensive trials are needed to confirm its potential in patients with TRD.
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Leprosy is a chronic granulomatous infectious disease with a proven role of Mycobacterium leprae invasion into endothelial cells. Animal studies have shown evidence of involvement of vasa nervorum in the process of nerve invasion. Capillaries act as the mirror image of vascular involvement in any rheumatic disorder and holds good for leprosy also. Nailfold capillaroscopy (NFC) is a non-invasive, easily reproducible technique to study proximal nailfold capillaries. The aim of this study is to investigate morphological nailfold capillaroscopic alterations in patients with leprosy in its various forms and comparison with the normal individual. Total 20 Leprosy patients and 20 normal age and sex matched individuals recruited for nailfold capillaroscopic examination using video dermoscopye. Among 20 normal individuals, 3(15%) individuals showed tortuous capillaries and microhemorrhages each, 2(10%) showed meandering vessels, 1(5%) each showed megacapillaries, dilated/ectatic capillaries and bizarre vessels. Out of 20 leprosy patients, 11 (55%) patients showed bizarre and meandering capillaries, 10(50%) showed dilated vessels and avascular areas, 9(45%) showed capillary dropouts and neovascularisation, 8(40%) showed tortuous vessels, 6(30%) haemorrhages and 4 (20%) showed megacapillaries. Findings like avascular areas, capillary dropouts, haemorrhages were more noticed in lepromatous and borderline lepromatous leprosy, whereas early capillary abnormalities like dilated, meandering, bizarre vessels and neoangiogenesis were noticed more in borderline tuberculoid leprosy. However, statistical significant difference between clinical and dermoscopic observations was not seen in this study. Further studies with a large sample size are required to find out the same. Morphological changes may denote micro-vascular invasion by Mycobacterium leprae and may act as warning signs of fore- coming complications like loss of sensation and trophic ulcers. Follow-up studies are required to understand such correlation, if any.
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The present research focused on the green, non-toxic, low-cost synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous extract of Hibiscus tiliaceus leaves as a reducing and stabilizing agent. Thus, synthesized ZnO NPs were characterized by nanotechnological applications, i.e., ultraviolet-visible spectroscopy (UV-vis), dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and high-resolution transmission electron microscopy (HR-TEM). The nanotechnological applications showed that as-synthesized ZnO NPs have bandgap energy of 2.97 eV, zeta potential of ?1.2 mV, crystalline in nature (JCPDS data card no-89-1397), and an average size of 30 to 60 nm. The FTIR showed that ZnO NPs have coated with plant secondary metabolites and assisted in the process of green synthesis. The ZnO NPs exhibited broad-spectrum antibacterial activity on Gram-positive and Gram-negative bacteria. The ZnO NPs showed potential anticancer activity against human breast cancer cells MCF-7 and determined the IC50 value as 65.83 ± 2.57 µg/mL by MTT assay. Furthermore, ZnO NPs were used as nano-catalyst for dye degradation of methylene blue, methyl orange, and malachite green with NABH4 as a reducing agent. The ZnO NPs exhibited potent dye degradation capability and followed pseudo-first order kinetics. The study concluded that ZnO NPs could be highly useful as anticancer and antibacterial agents in the biomedical field, and as an environmental cleaning agent for dye degradation in textile industries.
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Ayurveda- The science of life, has two aims, firstly it aimed at to preserve and protect the health of a healthy individual and secondly to cure the disease. As Ayurveda gives first priority to the preventive aspects to preserve and protect the health, it described preventive principles under the heading of Swasthavritta. Swasthavritta classically includes Dinacharya, Nishacharya and Ritucharya. These Charyas if followed properly, brings the balance in Thridosha (Vata, Pitta & Kapha) and thus maintains the Samadoshavastha (Homeostasis of humours/health). Thidoshas are always dynamic in nature, especially during seasonal variation. Adaptation to each Ritu is always a challenging to human beings, more in modern era, where people are running with mechanical life and exposing to pollutants. Ayurveda beautifully described Ritucharya prescription to be followed to bring balance in Tridoshavastha and also prevent morbid matter accumulation. There are six Rutus namely Sisira, Vasantha, Greeshma, Varsha, Sharat & Hemantha, among these, Sharat Ritu (mid-September - mid November) comes under the Visargakala constituting of Ashwini and Karthika Masa. In this Ritu physiologically Pitta undergoes Prakopa, if not followed Ritucharya properly, the Pitta will get vitiate and causes Pitta related diseases. In this article an honest attempt has been made to gather information regarding Sarat ritucahrya from all possible literature from Ayurvedic classics with practical aspects.
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Objective: Electroconvulsive therapy (ECT) is a well-established therapeutic intervention for major depressive disorder. Recent literature has shown that the anesthetic agent ketamine has some antidepressant properties at low doses and may be an alternative therapy for treatment-resistant major depressive disorder. We hypothesized that the use of low-dose ketamine as an anesthetic adjunct in ECT would more rapidly improve depression while maintaining hemodynamic stability than ECT with propofol alone. Methods: Institutional ethics approval was obtained, and the use of ketamine in this study was approved by Health Canada. This is a randomized, double-blinded, placebo-controlled trial that involved ketamine administration at 0.5 mg/kg IV in addition to propofol anesthesia for ECT. The primary outcome was the number of ECT treatments required to achieve a 50% reduction in the Montgomery-Asberg Depression Rating Scale (MADRS). Secondary outcomes included the number of ECT treatments required to achieve a 25% reduction in MADRS score, as well as any differences in the Clinical Global Impression Scale for Severity, hemodynamic variables, and seizure duration. Adverse events were recorded for safety assessment. Results: A total of 45 patients completed the study. No difference was found between groups with respect to the primary or secondary outcomes. The ketamine group showed a trend towards a decreased dose of propofol required to achieve adequate anesthesia. No adverse events were reported. Conclusion: Low-dose ketamine does not improve psychiatric outcomes in the setting of propofol-based anesthesia for ECT. Specifically, ketamine did not reduce the number of ECT sessions necessary to achieve a 50 or 25% reduction in MADRS scores. Reassuringly, the fact that no differences in hemodynamic variables or unexpected adverse events occurred suggests that low-dose ketamine may be safely used in this setting should clinical indications warrant its use. Clinical trial registration: ClinicalTrials.gov, NCT02579642
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The study is directed to establish the minimizing effects of Syzygium aromaticum, Ocimum sanctum, and Cananga odorata essential oils on the growth and ochratoxin A (OTA) level of Aspergillus ochraceus and Penicillium verrucosum in maize grains. S. aromaticum essential oil (SAEO), O. sanctum essential oil (OSEO), and C. odorata essential oil (COEO) were extracted by hydro-distillation technique, and a total of 50, 44, and 48 chemical constituents were identified by gas chromatography-mass spectrometry (GC-MS), respectively.The SAEO and OSEO belong to the chemotype of eugenol, whereas, COEO was found to be the chemotype of thymol, limonene, and ?-ylangene. The antifungal activity of essential oils (EOs) was determined by the micro-well dilution technique. The SAEO showed superior antifungal activity compared to OSEO, COEO, and synthetic antifungal agent nystatin, and its minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values against A. ochraceous and P. verrucosum were noticed as 1251 ± 42.32 and 1878 ± 28.47 µg/mL, and 0815 ± 22.69 and 1146 ± 51.19 µg/mL, respectively.The antifungal mechanism of EOs was unveiled by assessing the intracellular reactive oxygen species (ROS), ergosterol content, and membrane integrity. The antifungal investigations found that EOs caused fungal mortality by increasing the intracellular ROS, depleting ergosterol synthesis, and distracting membrane integrity. Finally, antifungal and antimycotoxin activity of EOs was demonstrated in maize grains. The SAEO, OSEO, and COEO have reduced the complete fungal growth and OTA level of A. ochraceous and P. verrucosum correspondingly at 2500 and 2500, 3500 and 2500, and 3500 and 3500 µg/g in maize. The EOs could act as natural antifungal agents; protect foodstuffs from fungal infection and mycotoxins during storage.
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Background:There is scarcity of essential medications, medical talent and health care facilities to treat covid-19, at remote places. This studyexplores various modalities in resource-limited settings for the management of COVID-19 patients.Methods: We retrospectively analysed data of 266 consecutive discharged and death Covid-19 patients from 26December 2020 to 29May 2021. All patients were admitted and received appropriate supportive care, regular clinical and laboratory monitoring.Results: Of total 266 patients the mean age of patients was 49.19 (SD 14.1) years and 185(69.54%) of them were males. 99(37%)cases were moderate, 83(31%)were severe cases remaining 84(32%)were mild cases. 16 (6.01%) patients expired and remaining 250 patients were subsequently discharged.Median duration of stay in the hospital was 9 (37) days. Of total 266 admitted patients� mortality rate was only 6.01%.Conclusions: We emphasize that even in healthcare facilities with limited resource, poor infrastructure and lack of ICU facilities, clinical observation-based managementt can help to reduce mortality considerably. Unique features of our study include; use of progesterone as an immunomodulator, use of dual antiviral agents, use of age-related lower limit of oxygen saturation.
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The strain VSM-25 with an exhilarating bioactive potential isolated during our systematic screening of marine actinomycetes was identified as Streptomonospora arabica based on polyphasic taxonomy. The ethyl acetate extract of culture filtrate was purified by silica gel column chromatography. The chemical structure of active compounds was determined by NMR, FTIR, and ESIMS and were established as Indole-3-carboxaldehyde (C1), 2, 3-dihydroxy benzoic acid (C2), Vanillic acid (C3), Daidzein (C4), and 3, 4-Dihydroxy benzaldehyde (C5). The antimicrobial activities of the compounds were tested against medicinally and agriculturally significant bacteria and fungi. C1 displayed a high inhibitory effect against bacteria and fungi to that of the other compounds tested. C5 exerted the strongest scavenging activity of free radicals such as DPPH and NO at a concentration of 400 µg/mL. C1 inhibited alpha-amylase effectively at 400 µg/mL although it was less potent than acarbose. C3 and C4 exerted significant anti-inflammatory and anti-arthritic activities at 400 µg/mL. The anti-inflammatory activity of compound C3 was found to be more potent than Diclofenac sodium, the reference drug. MTT assays of five compounds against MDA-MB-231 and MCF-7 cell lines using taxol as standard documented cytotoxicity. C4 showed highest activity of 67.81% and 54.33% (IC50 -1 µg/mL) against MDA-MB-231 and MCF-7. The cytotoxicity of five compounds was also evaluated by soft agar colony forming assay to determine the ability of MDA-MB-231 cells to proliferate while cell cycle arrest at sub G1 and induction of apoptosis was documented with MDA-MB-231 cells after treatment with C1, C2, C3, C4, and C5.
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The strain VSM-25 with an exhilarating bioactive potential isolated during our systematic screening of marine actinomycetes was identified as Streptomonospora arabica based on polyphasic taxonomy. The ethyl acetate extract of culture filtrate was purified by silica gel column chromatography. The chemical structure of active compounds was determined by NMR, FTIR, and ESIMS and were established as Indole-3-carboxaldehyde (C1), 2, 3-dihydroxy benzoic acid (C2), Vanillic acid (C3), Daidzein (C4), and 3, 4-Dihydroxy benzaldehyde (C5). The antimicrobial activities of the compounds were tested against medicinally and agriculturally significant bacteria and fungi. C1 displayed a high inhibitory effect against bacteria and fungi to that of the other compounds tested. C5 exerted the strongest scavenging activity of free radicals such as DPPH and NO at a concentration of 400 µg/mL. C1 inhibited alpha-amylase effectively at 400 µg/mL although it was less potent than acarbose. C3 and C4 exerted significant anti-inflammatory and anti-arthritic activities at 400 µg/mL. The anti-inflammatory activity of compound C3 was found to be more potent than Diclofenac sodium, the reference drug. MTT assays of five compounds against MDA-MB-231 and MCF-7 cell lines using taxol as standard documented cytotoxicity. C4 showed highest activity of 67.81% and 54.33% (IC50 -1 µg/mL) against MDA-MB-231 and MCF-7. The cytotoxicity of five compounds was also evaluated by soft agar colony forming assay to determine the ability of MDA-MB-231 cells to proliferate while cell cycle arrest at sub G1 and induction of apoptosis was documented with MDA-MB-231 cells after treatment with C1, C2, C3, C4, and C5.